Hypertension, fetal growth restriction (FGR), and fetal alcohol syndromeĥ. Group consisting of preeclampsia, gestational diabetes, gestational The method of claim 1, wherein said condition is selected from the (SEQ ID NO: 2 or 4) in said serum sample or said placenta tissue sampleĪs compared to a sample of a normal pregnant subject.Ĥ. Preeclampsia based on the presence of increased level of said sFlt-14 Not sFlt-1 (SEQ ID NO: 10) and (b) diagnosing said subject as having a Using an antibody capable of recognizing sFlt-14 (SEQ ID NO: 2 or 4) and A method of diagnosing preeclampsia in a subject in need thereof, theĢ or 4) in a serum sample or a placenta tissue sample of the subject Recognizing sFlt-14 (SEQ ID NO: 2 or 4) and not sFlt-1 (SEQ ID NO: 10) Īnd (b) diagnosing said subject as having a preeclampsia based on theģ. Method comprising: (a) detecting expression level of sFlt-14 (SEQ ID NO:Ģ or 4) in a biological sample of the subject using an agent capable of A method of diagnosing preeclampsia in a subject in need thereof, the Presence of increased level of said sFlt-14 (SEQ ID NO: 2 or 4) in saidīiological sample as compared to a sample of a normal pregnant subject.Ģ. Medical condition associated with maternal or fetal stress based on the Of recognizing sFlt-14 (SEQ ID NO: 2 or 4) and not sFlt-1 (SEQ ID NO:ġ0) and (b) diagnosing said subject as having a pregnancy-associated NO: 2 or 4) in a biological sample of the subject using an agent capable
The method comprising: (a) detecting expression level of sFlt-14 (SEQ ID A method of diagnosing a pregnancy-associated medical conditionĪssociated with maternal or fetal stress in a subject in need thereof, Hadasit Medical Research Services and Development Ltd. Hadasit Medical Research Services and Developm Yissum Research Development Company of the H KESHET ELI (MOSHAV AMINADAV, IL) ITIN AHUVA (JERUSALEM, IL) SELA SHAY (HAIFA, IL) YAGEL SIMCHA (JERUSALEM, IL) Pharmaceutical compositions, methods of diagnosing and treating Specifically binds the isolated polypeptide are also disclosed. Isolated antibody comprising an antigen recognition domain which A polynucleotide comprising a nucleic acid sequenceĬapable of specifically hybridizing to the isolated polynucleotide and an Homologous to SEQ ID NO: 4 and an isolated polynucleotide encoding sameĪre disclosed. VARIANTS OF VEGFR AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OFĪn isolated polypeptide comprising an amino acid sequence at least 70% United States Patent Application: 0130084583
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